منابع مشابه
Profile of Scott J. Hultgren.
During her lifetime, an adult woman has a 50% chance of developing a urinary tract infection—one of the most common types of infections (1). Most urinary tract infections are caused by strains of the bacterium Escherichia coli, and, for the most part, are easily treated with antibiotics. However, many of these infections become chronic or recurrent because of increasing antibiotic resistance an...
متن کاملProfile of R. Scott Hawley. Interview by Sujata Gupta.
M eiosis sets the stage for sexual reproduction through a trifold and tightly choreographed dance: Chromosomes from the mother and father form pairs, exchange genetic material, and then separate from their partners. Geneticist R. Scott Hawley, who has studied these three steps for the better part of his career, has dubbed the sequence a “meiotic ballet.” Although the dance steps have been known...
متن کاملLowe syndrome
Lowe syndrome (the oculocerebrorenal syndrome of Lowe, OCRL) is a multisystem disorder characterised by anomalies affecting the eye, the nervous system and the kidney. It is a uncommon, panethnic, X-linked disease, with estimated prevalence in the general population of approximately 1 in 500,000. Bilateral cataract and severe hypotonia are present at birth. In the subsequent weeks or months, a ...
متن کاملInhibitor profile of porcine aminopeptidase W.
Aminopeptidase W (APW; EC 3.4.1 I . 16) belongs to the family of mammalian cell-surface zinc metallopeptidases [ 13. These enzymes are involved in a number of different processes depending upon their location, metabolizing a range of different biologically active peptides including peptide hormones, neuropeptides and dietary peptides. Some of these cell-surface peptidases are proving to be impo...
متن کاملLowe syndrome
Lowe syndrome (LS) is a lethal X-linked genetic disease caused by functional deficiencies of the phosphatidlyinositol 5-phosphatase, Ocrl1. In the past four years, our lab described the first Ocrl1-specific cellular phenotypes using dermal fibroblasts from LS patients. These phenotypes, validated in an ocrl1-morphant zebrafish model, included membrane remodeling (cell migration/spreading, fluid...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1721809115